Novel Molecular Targets for Immune Surveillance of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a common and aggressive cancer with high mortality rate. The incidence of HCC increasing worldwide, the lack effective screening programs often results in delayed diagnosis, making it challenging disease to manage. Immunotherapy has emerged as promising treatment option for different kinds cancers, potential stimulate immune system target cells. However, current immunotherapeutic approaches have shown limited efficacy. Since arises within complex tumour microenvironment (TME) characterized by presence various stromal cell types, understanding this interaction crucial identification therapy. In review, we highlight recent advances our TME cells involved anti-tumour responses, including new possible targets immunotherapy. We illustrate classification based on infiltration give evidence about role SerpinB3, serine protease inhibitor regulation response cancers.